Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation

The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern reaction conditions and slow rate Fenton (pH 3-4). Herein, we report an ultrasmall trimetallic (Pd, Cu, Fe) alloy nanozyme (PCF-a NEs) possessing dynamic active-site synergism, thus exhibiting a cascade glutathione peroxidase (POD) mimicking activities in circumneutral pH. PCF-a NEs exhibit photothermally augmented POD property high photothermal conversion efficiency (62%) for synergistic tumor cell apoptosis. In addition, ultrasound can also enhance mass transfer at active catalytic sites NEs, turn accelerating Fenton-like tumor-specific CDT. This work provides strategy engineering nanozymes bioinspired way amplification intratumor reactive oxygen species response to external stimuli, demonstrating enhanced inhibition growth vitro vivo.